Drug Delivery to Brain Tumor: Challenges and Recent Developments

Drug delivery for brain tumors is a questionable subject which is the major barrier in treatment. Nowadays, a lot of proposals have been developed to increase the amount of intravascular drug reaching the tumor. All drugs have a common disadvantage, only a small amount of delivered drug actually reaches the tumor. The systemic toxicity is the main doselimiting factor. When we are given directly into the tumor or into the cerebrospinal fluid then 100% of the administered dose is reached to the objective site. So the delivery is connected the spatial distribution and also in the change in drug concentration. The major dose-limiting factor of most local delivery methods will be neurotoxicity. The comparative advantages and disadvantages of the different methods of Drug delivery for brain tumors are presented in this review.